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Dementia at old age: a clinical end-point of atherosclerotic disease

G.J. Blauw, E.L.E.M. Bollen, M.A. van Buchem, R.G.J. Westendorp
DOI: http://dx.doi.org/10.1016/S1520-765X(01)90133-6 N16-N19 First published online: 1 November 2001


The main causes of dementia at old age are Alzheimer's disease and vascular dementia. The clinical presentations of late-onset Alzheimer's disease and vascular dementia can barely be differentiated. This clinical observation is supported by pathological findings. Late-onset dementia should be considered a multifactorial disease, in which both vascular factors and amyloid dispositions contribute to cognitive decline.

  • Alzheimer's disease
  • atherosclerosis
  • 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins)
  • pravastatin
  • vascular dementia