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Introduction
E-mail address: christoph.bode@uniklinik-freiburg.de
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Atherothrombotic disease is the leading cause of cardiovascular disorders and related deaths worldwide; its prevalence is increasing in society primarily because of the aging demographic. Humans have evolved a highly efficient coagulation system to prevent unwanted bleeding, but this system is also reactive with damaged endothelium and atherosclerotic plaque. These can lead to platelet activation, and ultimately clot formation, resulting in thrombotic events. Antiplatelet therapies have therefore become a cornerstone of treatment for atherothrombotic disease, and the benefits of currently available antiplatelet agents (including aspirin, irreversible thienopyridine ADP receptor antagonists, and glycoprotein
University Hospital
Freiburg
Germany