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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: permissions@oupjournals.org

Editorial

If inhibition: from pure heart reduction to treatment of stable angina

Michal Tendera*

Third Department of Cardiology, Silesian School of Medicine, Ziolowa 47, 40-635 Katowice, Poland

* Corresponding author. Tel: +48 32 2523930; fax: +48 32 202 3060. E-mail address: mtendera@kardio3.katowice.pl

The first 150 words of the full text of this article appear below.

Heart rate: prognostic role in health and disease

Population studies have shown that accelerated resting heart rate is associated with increased all-cause and cardiovascular mortalities.1–4 Moreover, there is an increasing body of evidence that tachycardia is not merely an indicator of an increased mortality, but actually contributes to a worse prognosis. Several potential mechanisms may be involved in this process. It appears that all living creatures have a limited number of heartbeats in their lifetime.5 In the cardiovascular system, a high heart rate may promote development of atherosclerotic lesions and induce cardiomyopathy and arrhythmias.

In patients with coronary artery disease, the relationship between heart rate and mortality is even more established. In a large recently published study6 conducted in patients with established or suspected coronary atherosclerosis, heart rate at rest was an independent factor predicting survival. In this group, increased heart rate not only induces ischaemia but also predisposes to plaque rupture, and therefore, triggers acute coronary events, . . . [Full Text of this Article]

Role of elevated heart rate in ischaemic heart disease

Stable angina: magnitude of the problem, current treatment, and unmet needs

Concept of If inhibition


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