The European Society of Cardiology
Introduction
a Department of Cardiology, Heart Centre, University Medical Centre, P.O. Box 9101, St. Radboud, Nijmegen, The Netherlands
b Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
* Tel.: +31-24-361-4220; fax: +31-24-354-0537
f.verheugt@cardio.umcn.nl
eantman@rics.bwh.harvard.edu
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Arterial thrombosis is the underlying pathophysiological cause behind coronary arterial disease and ischaemic stroke, and arises as a result of a complex interplay between the ruptured arterial plaque, activation of platelets, and the coagulation cascade. Given the central role that coagulation factor thrombin (Factor ll) plays in thombus formation via fibrin formation and platelet activation, anticoagulant