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The European Society of Cardiology

Introduction

Freek W.A. Verheugta,* and Elliott M. Antmanb

a Department of Cardiology, Heart Centre, University Medical Centre, P.O. Box 9101, St. Radboud, Nijmegen, The Netherlands
b Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

* Tel.: +31-24-361-4220; fax: +31-24-354-0537
f.verheugt@cardio.umcn.nl

eantman@rics.bwh.harvard.edu

The first 10% of the full text of this article appears below.

Arterial thrombosis is the underlying pathophysiological cause behind coronary arterial disease and ischaemic stroke, and arises as a result of a complex interplay between the ruptured arterial plaque, activation of platelets, and the coagulation cascade. Given the central role that coagulation factor thrombin (Factor ll) plays in thombus formation via fibrin formation and platelet activation, anticoagulant . . . [Full Text of this Article]


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