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Clonality of T lymphocytes in inflammatory cardiomyopathy

Y. Matsumoto*

Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan

* Correspondence: Yoh Matsumoto, Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6 Fuchu, Tokyo 183-8526, Japan.

Abstract

Identification of T-cell receptors (TCRs) of autoimmune disease-inducing T cells within a short period of time is a key factor in designing TCR-based immunotherapy during the course of disease. In the present study the experimental autoimmune carditis-associated TCRs Vbeta8.2 and Vbeta10 were identified by CDR3 spectratyping analysis. Immunotherapy targeting both Vbeta8.2 and Vbeta10 TCRs using DNA vaccines significantly reduced the histological severity of experimental autoimmune carditis and completely suppressed inflammation in some animals. TCR-based immunotherapy following rapid identification of autoimmune disease-associated TCRs by CDR3 spectratyping may be applicable not only in animal but also in human autoimmune diseases with pathological mechanisms that are poorly understood.

Key Words: Autoimmune • myocarditis • T cell receptor • repertoire • T cell receptor based DNA vaccination


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