Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow References
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Matsumori, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Matsumori, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Cytokines in myocarditis and dilated cardiomyopathy

A. Matsumori*

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

* Correspondence: Akira Matsumori, MD, PhD, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto 606-8397, Japan.

Abstract

Cytokines have been found to play an important role in the pathogenesis and pathophysiology of myocarditis and dilated cardiomyopathy. Persistent expressions of proinflammatory cytokines were seen in animal models of these diseases. IL-10 suppressed the expression of cytokines and improved viral myocarditis. A phosphodiesterase inhibitor, pimobendan, prolonged survival and attenuated inflammatory lesions and the production of intra-cardiac cytokines. The inhibitory effect was explained by its inhibitory effect on the activation of NF-kappa B. Cytokine gene therapy by in vivo electroporation is a promising treatment for viral myocarditis.

Key Words: Cytokines • NF-kappa B • myocarditis • cardiomyopathy • gene therapy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.