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Drug-induced torsade de pointes: the perspectives of industry

J.T. Barbey*

Division of Chemical Pharmacology, Georgetown University, Washington, DC, U.S.A

* Correspondence: Jean T. Barbey, MD, Assistant Professor of Medicine and Pharmacology, Division of Clinical Pharmacology, Georgetown University, 3900 Reservoir Road, Washington, DC 20007, U.S.A.

Abstract

In 1996 the Committee for Proprietary Medicinal Products published their ‘Points to consider’ which have been used as unofficial guidelines by drug companies developing new pharmacologic compounds. Recommendaitons endorsed by the CPMP regarding hand measurement of the QT interval, QT dispersion, the Bazett QT interval correction for heart rate and the use of signal values for QTc changes compared to baseline are discussed in this paper.

Key Words: ‘Points to consider’ • QT interval measurements


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