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© The European Society of Cardiology 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Metabolic syndrome: the dysmetabolic state of dysfunctional adipose tissue and insulin resistance

Jean-Pierre Després and H. Bryan Brewer

The first 10% of the full text of this article appears below.

The current world epidemic of obesity represents a tremendous medical and public health challenge. A major consequence of obesity has been a rapid acceleration in the prevalence of type 2 diabetes;1 however, it is now recognized that even before the development of diabetes, many individuals have the constellation of athero-thrombotic inflammatory abnormalities characteristic of type 2 diabetes.2 Thus, the cluster of metabolic abnormalities is not the consequence of the hyperglycaemic state of type 2 diabetes but is rather pathophysiologically related to insulin resistance, the most prevalent form of insulin resistance being present in individuals with excess visceral as well as ectopic fat.3 Thus, even in the absence of hyperglycaemia, abdominally obese patients with an excess of visceral and ectopic fat . . . [Full Text of this Article]


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