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Lessons from GRACE: the Global Registry of Acute Coronary Events

K. Eagle*

University of Michigan School of Medicine, Ann Arbor Michigan, USA

* Correspondence: Kim Eagle, MD, University of Michigan School of Medicine, A. Alfred Taubman Health Care Center, 1500 East Medical Center Drive, Room TC 3910, Ann Arbor, MI 48109-0366, USA

Abstract

Several coronary heart disease registries have gathered data on specific aspects of heart disease, but none has looked at the spectrum of acute coronary syndromes. Since June 1999, the Global Registry of Acute Coronary Events (GRACE) has been collecting clinical data on patients with unstable angina, non-ST-elevation myocardial infarction and ST-elevation myocardial infarction. GRACE gathers data from 94 hospitals in 14 countries on current practices of care provided to patients with acute coronary syndromes. This report reviews the origins, values and limitations of disease registries; summarizes the objectives of GRACE; and presents preliminary data obtained in the first 13,000-plus patients enrolled in the registry.

Key Words: Coronary disease • heart disease • myocardial ischaemia • registries

References

  1. Langmuir AD. William Farr:founder of modern concepts of surveillance. Int J Epidemiol. 1976;5:13–18[Abstract/Free Full Text]
  2. Susser M, Adelstein A. An introduction to the work of William Farr. Am J Epidemiol. 1975;101:469–476[Free Full Text]
  3. Thacker SB. Historical development. Churchill RE. Principles and Practice of Public Health Surveillance. 2nd Edition. New York: Oxford University Press; 2000. p. 1–16
  4. Wagner G. Cancer registration: historical aspects. IARC Sci Publ. 1985;:3–12
  5. Teutsch SM. Considerations in planning a surveillance system. Churchill RE. Principles and Practice of Public Health Surveillance. 2nd Edition. New York: Oxford University Press; 2000. p. 17–26
  6. Berkelman RE, Stroup DF, Buehler JW. Public health surveillance. Omenn GS. Oxford Textbook of Public Health. 3rd Edition. New York: Oxford University Press; 1997. p. 735–750
  7. Birkhead GS, Maylahn CM. State and local public health surveillance. Churchill RE. Principles and Practice of Public Health Surveillance. 2nd Edition. New York: Oxford University Press; 2000. p. 253–286
  8. Dyke CK, Calif RM. National and regional registries: what good are they? Eur Heart J. 2000;21:1401–1403[Free Full Text]
  9. Hearst N, Grady D, Barron HV, et al. Research using existing data: secondary data analysis, ancillary studies, and systematic reviews. Newman TB. Designing Clinical Research: An Epidemiologic Approach. 2nd Edition. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 195–212
  10. Dawson BD, Trapp R. Basic and Clinical Biostatistics. 3rd Edition. New York: Lange Medical Books/McGraw Hill; 2001. p. 7–23
  11. Cummings SR, Newman TB, Hulley SB. Designing an observational study: cohort studies. Newman TB. Designing Clinical Research: An Epidemiologic Approach. 2nd Edition. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 95–105
  12. Newman TB, Browner WS, Cummings SR, et al. Designing an observational study: cross-sectional and case-control studies. Newman TB. Designing Clinical Research: An Epidemiologic Approach. 2nd Edition. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 107–123
  13. Cummings SR, Grady D, Hulley SB. Designing an experiment: clinical trials I. Newman TB. Designing Clinical Research: An Epidemiologic Approach. 2nd Edition. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 143–155
  14. Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring Trends and Determinants in Cardiovascular Disease. Lancet. 1999;353:1547–1557[CrossRef][Web of Science][Medline]
  15. Tunstall-Pedoe H. Monitoring trends in cardiovascular disease and risk factors: the WHO ‘Monica’ project. WHO Chron. 1985;39:3–5[Web of Science][Medline]
  16. Tunstall-Pedoe H, Vanuzzo D, Hobbs M, et al. Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations. Lancet. 2000;355:688–700[CrossRef][Web of Science][Medline]
  17. Brindis RG, Fitzgerald S, Anderson HV, Shaw RE, Weintraub WS, Williams JF. The American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR): building a national clinical data repository. J Am Coll Cardiol. 2001;37:2240–2245[Free Full Text]
  18. Rogers WJ, Canto JG, Lambrew CT, et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J Am Coll Cardiol. 2000;36:2056–2063[Abstract/Free Full Text]
  19. Finlay A, Cosovich C, Gebur S. A national disease registry moves beyond clinical impact, fostering measurable cost savings at the community hospital level. J Health Care Finance. 2000;27:8–29[Medline]
  20. Anand SS. The Organization to Assess Strategies for Ischemic Syndromes (OASIS) pilot study: evaluation of acute and longterm therapies for patients with acute coronary syndromes without ST elevation. Am J Cardiol. 1999;84:13M–19M[Web of Science][Medline]
  21. Collinson J, Flather MD, Fox KA, et al. Clinical outcomes, risk stratification and practice patterns of unstable angina and myocardial infarction without ST elevation: Prospective Registry of Acute Ischaemic Syndromes in the UK (PRAIS-UK). Eur Heart J. 2000;21:1450–1457[Abstract/Free Full Text]
  22. Fox KA, Cokkinos DV, Deckers J, Keil U, Maggioni A, Steg G. The ENACT study: a pan-European survey of acute coronary syndromes. European Network for Acute Coronary Treatment. Eur Heart J. 2000;21:1440–1449[Abstract/Free Full Text]
  23. Fox KAA. An introduction to the Global Registry of Acute Coronary Events: GRACE. Eur Heart J Suppl. 2000;2:F21–F24
  24. Granger CB. Strategies of patient care in acute coronary syndromes: rationale for the Global Registry of Acute Coronary Events (GRACE) registry. Am J Cardiol. 2000;86:4M–9M[Web of Science][Medline]
  25. AnonymousAm Heart J. 2001;141:190–199[CrossRef][Web of Science][Medline]
  26. Ryan TJ, Antman EM, Brooks NH, et al. 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol. 1999;34:890–911[Free Full Text]
  27. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol. 2000;36:970–1062[Free Full Text]
  28. Cohen M, Demers C, Gurfinkel EP, et al. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. N Engl J Med. 1997;337:447–452[Abstract/Free Full Text]
  29. Antman EM, McCabe CH, Gurfinkel EP, et al. Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial. Circulation. 1999;100:1593–1601[Abstract/Free Full Text]
  30. Sadiq I, Eagle KA, Agnelli G, et al. Role of glycoprotein IIb/IIIa antagonists in patients with acute coronary syndromes: comparison of clinical trial data with the global registry of acute coronary events (GRACE). [abstract]Eur Heart J. 2001;22:519
  31. Cannon CP, Van de Werf F, Avezum A, et al. Safety of the combination of low-molecular-weight heparin and glycoprotein IIb/IIIa inhibitors: observations from the global registry of acute coronary events (GRACE). [abstract]Eur Heart J. 2001;22:592

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BMJ, March 31, 2007; 334(7595): 647 - 648.
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This Article
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