Skip Navigation

This Article
Right arrow Abstract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Diebold, B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Diebold, B.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Feasibility and possible cost-effectiveness of contrast echocardiography in the emergency room for the evaluation of chest pain syndromes

B. Diebold*

Hôpital Européen Georges Pompidou, Paris, France

* Correspondence: Professor Benoit Diebold, Hôpital Européen Georges Pompidou, Service de Cardiologie, 20 rue Leblanc, 75 908 Paris Cedex 15.

Abstract

The identification of a segmental wall motion abnormality has not thus far gained confidence in routine practice for the dignosis of acute myocardial infarction because of suboptimal sensitivity, in particular in patients with poor echogenicity. Recently developed contrast media have demonstrated a positive impact on this relatively low sensitivity. This improvement might lead to the introduction of contrast echocardiography in ‘rule out myocardial infarction’ protocols, provided that users are adequately trained. In patients with unstable angina and normal troponin values, a stress test is recommended to decide on the strategy. Stress echocardiography reportedly has both better sensitivity and specificity than exercise ECG, and has an overall accuracy similar to that of nuclear medicine. Because contrast further improves the performance of stress echocardiography, it might further decrease the need for nuclear medicine in the case of poorly delineated endocardium.

Key Words: Chset pain unit • contrast echocardiography • left ventricular opacification • myocardial perfusion

References

  1. Braunwald E, Antan EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: executive summary and recommendations. Circulation. 2000;102:1193–1209[Free Full Text]
  2. Hundley WG, Kizilbash AM, Afridi I, et al. Administration of an intravenous perfluorocarbon contrast agent improves echocardiographic determination of left ventricular volumes and ejection fraction: comparison with cine magnetic resonance imaging. J Am Coll Cardiol. 1998;32:1426–1432[Abstract/Free Full Text]
  3. Lafitte S, Dos Santos P, Kerouani A, et al. Improved reliability for echocardiographic measurement of left ventricular volume using harmonic power imaging mode combined with contrast agent. Am J Cardiol. 2000;85:1234–1238[CrossRef][Web of Science][Medline]
  4. Daniel GK, Chawla MK, Sawada SG, et al. Echocardiographic imaging of technically difficult patients in the intensive care unit: use of OptisonTM in combination with fundamental and harmonic imaging. J Am Soc Echocardiogr. 2001;14:917–920[CrossRef][Web of Science][Medline]
  5. Nahar T, Croft LB, Shapiro R, et al. Accurate quantitative echocardiography requires harmonic contrast imaging. [abstract]J Am Coll Cardiol. 2000;35(suppl A):1189
  6. Lancellotti P, Seidel L, Hoffer E, et al. Clinical and prognostic implications of semi-supine exercise stress echocardiography for the evaluation of chest pain in the emergency room. [abstract]Eur Heart J. 2000;21(suppl 19):209
  7. Ikonomidis I, Holmes E, Narbuvold H, et al. Assessment of left ventricular wall motion and delineation of the endocardial border after intravenous injection of Infoson during dobutamine stress echocardiography. Coron Artery Dis. 1998;9:567–576[Web of Science][Medline]
  8. Dolan MS, Riad K, El-Shafci A, et al. Effect of intravenous contrast for left ventricular opacification and border definition on sensitivity and specificity of dobutamine stress echocardiography compared with coronary angiography in technically difficult patients. Am Heart J. 2001;142:908–915[CrossRef][Web of Science][Medline]
  9. Shaw L, Mulvaugh S, Jacobson C, et al. Cost implications of diagnosing coronary disease. [abstract]Eur Heart J. 2000;21:477–2564 (suppl)
  10. Villareal RP, Mesa A, Hernandez A, et al. Optison® enhanced echocardiography: a cost-effective approach to non-invasive testing. [abstract]J Am Coll Cardiol. 2000;35(suppl A):1189
  11. Marwick TH, Brunken R, Meland N, et al. Accuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice: comparison with wall motion and technetium-99m sestamibi single-photon emission computed tomography. J Am Coll Cardiol. 1998;32:1260–1269[Abstract/Free Full Text]
  12. Sheila K, Heinle SK, Noblin J, et al. Assessment of myocardial perfusion by power Doppler harmonic imaging at rest and during adenosine stress. [abstract]J Am Coll Cardiol. 2000;35(suppl A):867
  13. Dent JM, Thorpe J, Doss A, et al. Myocardial contrast echocardiography with continuous infusion of Optison and variable pulsing intervals: experience with first 200 cases undergoing 99mTc-sestamibi-SPECT. [abstract]J Am Coll Cardiol. 2000;35(suppl A):867
  14. Dawson D, Wei K, Thorpe J, et al. Detection of coronary artery disease using real-lime myocardial contrast echocardiography: comparison with dipyridamole stress sestamibi SPECT. Circulation. 2000;102:2626
  15. Ronderos R, Boskis M, Chung N, et al. Correlation between intermittent imaging using intravenous perfluorocarbon microbubbles and radioisotope imaging in the detection of myocardial perfusion abnormalities during dypiridamole stress echo. [abstract]Eur Heart J. 2000;21:235–1290 (suppl)
  16. Hinchman D, Kontos M, Kunningham M, et al. Concordance of myocardial echocardiography using Optison with SPECT for detecting ischemia in acute chest pain emergency room patients. Circulation. 1998;17:1–77
  17. Duca MD, Giri S, Wu AH, et al. Comparison of acute rest myocardial perfusion imaging and serum markers of myocardial injury in patients with chest pain syndromes. J Nucl Cardiol. 1999;6:570–575[CrossRef][Web of Science][Medline]
  18. Abbott BG, Abdel-Aziz I, Monico EP, Wackers FJT. Judicious use of radionuclide perfusion imaging in a emergency department chest pain center optimizes the triage of patients with chest pain. J Am Coll Cardiol. 2000;35(suppl A):884
  19. Stowers SA, Eisenstein EL, Wackers FJ, et al. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: results from a randomized trial. Ann Emerg Med. 2000;35:17–25[CrossRef][Web of Science][Medline]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?



This Article
Right arrow Abstract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Diebold, B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Diebold, B.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?