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The European Society of Cardiology

A research project focusing on uncommon aspects and novel markers in congestive heart failure

Critical evaluation of multicentre research management

L. Tavazzia,* and E. Arbustinib

a Department of Cardiology, IRCCS Policlinico San Matteo, Pavia, Italy
b Molecular Diagnostics, Cardiovascular and Transplant Pathology Laboratory, Transplant Research Area, IRCCS Policlinico San Matteo, Pavia, Italy

* Correspondence: Tel.: +39 382 503157; fax: +39 382 503159 (E-mail: l.tavazzi@smatteo.pv.it).

The first 150 words of the full text of this article appear below.

Introduction

In 1999, a research project was funded by the Ministry of Health to the Institute of Research and Care University Hospital Policlinico San Matteo of Pavia with the aim of focusing on translational, orphan and modelling research in congestive heart failure (CHF). Centres involved in the project had the specific objectives of contributing to:

• the aetiology and diagnosis, by investigating:
– animal models of frequent CHF-causing disease (the ischemic model);
– clinical models (based on non-invasive tools) that could address clinicians to the identification of familial and non-familial forms with the specific aim of better oriented aetiological research, early diagnosis, and prevention of adverse events;
– non-cardiac diagnostic tools that could help aetiology identification: the skeletal muscle biopsy in patients with dilated cardiomyopathy,

• highlight the patho-physiology of CHF:
– right ventricular dysfunction, immune activation, and mechanism of arterial stiffness in CHF;
– spontaneous human models able to provide . . . [Full Text of this Article]

Materials and methods

Results

Scientific results

Discussion


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