Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org
Cardiovascular protection by angiotensin-converting enzyme inhibition
Department of Cardiology, University of Ferrara, and Salvatore Maugeri Foundation, IRCCS, Ferrara, Italy
* Corresponding author. E-mail address: fri@unife.it
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One of the most important health achievements during the twentieth century was the unravelling of the causes of the cardiovascular diseases (CVDs). Since the 1980s, coronary artery disease (CAD) mortality rates have been reduced in many developed countries and have fallen by 75% in countries such as Finland.1 Modern cardiovascular treatment has played an important role. The explosion in evidence-based treatments since the 1980s has provided us with the tools to increase life expectancy in those affected by the disease. The discovery of angiotensin-converting enzyme (ACE) inhibitors is one of these important tools. Ironically, ACE inhibitors come from the veins of poisonous snakes and yet their widespread use has saved millions of patients. Again, ironically, ACEs and the renin–angiotensin system have been and still are phylogenetically pivotal for the preservation of the species and for