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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The cell and molecular biology of right ventricular dysfunction in pulmonary hypertension

Sheila G. Haworth

Developmental Cardiology, Institute of Child Health, University College London, London, UK and Department of Paediatric Cardiology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK

Corresponding author. Tel: +44 207 405 9200.E-mail address: s.haworth{at}ich.ucl.ac.uk

Pulmonary vascular disease is accompanied by structural remodelling and dysfunction of the right ventricle. Current non-invasive studies describe the global performance of the right ventricle but do not explain the cell and molecular abnormalities which we need to understand if we are to develop therapeutic strategies to improve right ventricular function. This review attempt to summarise current opinion and in doing so emphasises the paucity of information specific to this ventricle.

Key Words: Right ventricle • Pulmonary hypertension • Ventricular remodelling


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