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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

G-CSF in the setting of acute myocardial infarction

Hüseyin Ince*, Tim C. Rehders, Stephan Kische, Stephan Drawert, Esther Adolf, Tilo Kleinfeldt, Michael Petzsch and Christoph A. Nienaber

Department of Medicine, Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Ernst-Heydemann-Str. 6, 18057 Rostock, Germany

* Corresponding author. Tel: +49 381 494 7701; fax: +49 381 494 7702.E-mail address: hueseyin.ince{at}med.uni-rostock.de

Experimental data suggest that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) may have potential as a novel regenerative strategy in the setting of acute myocardial infarction (AMI). Potentially beneficial effects of G-CSF may be attributed mainly to direct action of the cytokine G-CSF on injured myocardium by inhibition of apoptosis, rather than to differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews potential cardioprotective effects of G-CSF and discusses experimental and clinical findings with G-CSF in the setting of AMI.

Key Words: G-CSF • Acute myocardial infarction • Cytokines • Stem cells


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