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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Intramyocardial bone marrow stem cell treatment for myocardial regeneration

Gustav Steinhoff1,*, Yeong-Hoon Choi1 and Christof Stamm2

1 Department of Cardiac Surgery, Klinik und Poliklinik für Herzchirurgie, Medizinische Fakultät, University of Rostock, Schillingallee 35, 18057 Rostock, Germany
2 German Heart Center Berlin, Berlin, Germany

* Corresponding author. Tel: +49 381 494 6101; fax: +49 381 494 6102. E-mail address: gustav.steinhoff{at}med.uni-rostock.de

Transplantation of stem cells has been shown by substantial experimental evidence as well as by initial clinical studies to improve cardiac function in patients with post-infarction myocardial injury. Both angiogenic and myogenic properties of bone-marrow-derived stem cells have been evidenced to be involved in its beneficial effect on heart function after transplantation into area of ischaemic injury. This paper summarizes the current knowledge on the mechanisms involved in regenerative potential of bone-marrow-derived stem cells, with special attention to the clinical experience with cell transplantation during cardiac surgery.

Key Words: Stem cells • Angiogenesis • Myogenesis • Cardiac surgery • Heart failure


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