Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Bassand, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Bassand, J.-P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Drug interactions in the setting of acute coronary syndromes and dual anti-platelet therapy

Jean-Pierre Bassand

Department of Cardiology, University Hospital Jean Minjoz, Boulevard Fleming, 25000 Besançon, France

Corresponding author. Tel: +33 381 668 539; fax: +33 381 668 582. E-mail address: jean-pierre.bassand{at}ufc-chu.univ-fcomte.fr

Modern treatment of acute coronary syndromes (ACS) with or without ST-segment elevation involves the use of at least five pharmacological groups during the acute phase, namely anti-platelet agents (including aspirin and clopidogrel), anti-thrombotic agents (unfractionated heparin, enoxaparin or fondaparinux), beta-blockers and/or calcium channel blockers, ACE inhibitors, and statins. Long term treatment also involves the same combination of drugs, except anti-thrombins. Few interactions have been described between these drugs. In particular, interactions between clopidogrel and statins described in vitro have never been shown to have any clinical implications. In fact, the two drugs have been shown clinically to have an additional effect. Non-steroidal anti-inflammatory drugs should, however, be used with caution, due to possible interactions with aspirin.

Key Words: Clopidogrel • Drug interactions • Pharmacokinetics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.