Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Reasner, C. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Reasner, C. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Niaspan®: a powerful treatment option for ‘diabetic dyslipidaemia’

Charles A. Reasner*

Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78282-7877, USA

* Corresponding author. Tel: +1 210 358 7402; fax: +1 210 358 7406. E-mail address: charles.reasner{at}uhs-sa.com

Low HDL-cholesterol is a common feature of the dyslipidaemia commonly encountered in patients with type 2 diabetes or the metabolic syndrome. Nicotinic acid, the most effective agent available for increasing levels of HDL-cholesterol, has been shown to improve cardiovascular outcomes in major outcome trials. These benefits are observed in patients with or without diabetes, and the magnitude of the outcome benefit was unaffected by changes in glycaemia during treatment. Niaspan® is a new prolonged-release formulation of nicotinic acid with equivalent efficacy and superior tolerability compared with the older, immediate-release formulation. Well-designed trials and retrospective analyses have shown that Niaspan, given alone or with a statin, improves HDL-cholesterol and other lipid components in patients with diabetes or the metabolic syndrome, resulting in a less atherogenic lipid profile. The changes in glycaemia during treatment with Niaspan are minimal and can be easily corrected by adjustments to antidiabetic medications. Niaspan provides a potent and practical means of correcting low HDL-cholesterol in patients with dysglycaemia.

Key Words: Type 2 diabetes • Dyslipidaemia • HDL-cholesterol • Nicotinic acid • Niacin • Metabolic syndrome


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.