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The European Society of Cardiology

Impact of cardiopulmonary exercise testing on patient selection for cardiac resynchronisation therapy

Barbara Lamp*, Jürgen Vogt, Henning Schmidt and Dieter Horstkotte

Department of Cardiology, Heart Centre North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany

Received 3 May 2004; accepted 24 May 2004.

* B. Lamp, Department of Cardiology, Heart Center North Rhine-Westphalia, Ruhr University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany. Tel.: +49-5731-97-1258; fax: +49-5731-97-2194
blamp{at}hdz-nrw.de

Abstract

In patients with systolic heart failure the assessment of peak oxygen consumption during cardiopulmonary exercise (CPX) testing provides an objective measure of functional capacity and important prognostic information. Several studies in pacemaker therapy and in cardiac resynchronization therapy (CRT) have used peak oxygen uptake as an endpoint. This article reviews the impact of CPX testing on patient selection for CRT.

Key Words: Heart failure • Left bundle branch block (LBBB) • Cardiopulmonary exercise testing • Cardiac resynchronisation therapy

List of Abbreviations: HF heart failure • CPX cardiopulmonary exercise • ECG electrocardiogramme • CO cardiac output • VO2 oxygen uptake • VE minute ventilation • VCO2 carbon dioxide output • EF ejection fraction • CO2 carbon dioxide • BNP brain natriuretic peptide • DCM dilated cardiomyopathy • ICM ischaemic cardiomyopathy • CRT cardiac resynchronisation therapy • LVEDD left ventricular enddiastolic diameter • PATH-CHF Pacing Therapies for Congestive Heart Failure (Study) • COMPANION Comparison of Medical Therapy Pacing and Defibrillation in Chronic Heart Failure (Study)


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