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Anticoagulation in atrial fibrillation: what is certain and what is to come

G.Q. Villani*, M. Piepoli, P.E. Villani and A. Capucci

Divisione di Cardiologia, Ospedale Civile, Piacenza, Italy

* Dr Giovanni Quinto Villani, Divisione di Cardiologia, Ospedale Civile, Via Taverna 49, 29100 Piacenza, Italy

Abstract

Thromboembolism is the major complication in atrial fibrillation, prevention of which constitutes a major challenge in the modern treatment of this common arrhythmia. Treatment with oral anticoagulation is considered the ‘gold standard’, although several controversial issues have been raised concerning its use in all subgroups of patients affected by atrial fibrillation. In this review, the ‘state of the art’ treatment strategies in this important and potentially lethal clinical complication are discussed, with particular attention given to issues that remain unresolved. Finally, current proven and accepted therapeutic approaches are presented.

Key Words: Atrial fibrillation • Anticoagulant therapy


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