Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow References
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Knöll, R.
Right arrow Articles by Chien, K.R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Knöll, R.
Right arrow Articles by Chien, K.R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Z-line proteins: implications for additional functions

R. Knöll, M. Hoshijima and K.R. Chien*

Institute of Molecular Medicine, University of California at San Diego, California, U.S.A.

* Correspondence: Kenneth R. Chien, University of California at San Diego, Institute of Molecular Medicine, Basic Science Building 0641, 9500 Gilman Drive, California 92093, USA

Abstract

Z-line proteins have important structural functions. However, recent publications point to additional, previously unexpected functions and a new view is now emerging, whereby these proteins are involved in important intra- and inter-cellular signaling pathways. Their translocation to the nucleus, the interaction with other signaling molecules and the ability to facilitate macromolecular protein complexes indicate the multi-functionality of Z-line proteins. A better understanding of these emerging physiological roles of Z-line proteins might be achieved by precise investigations of specific mutations in specific domains in a subset of these proteins. Clues will be given to explain the clinical variations in the development and severity of different forms of cardiomyopathies, which are also affected by genetic redundancy and ethnic background of different patient populations.

Key Words: Z-line • DCM • heart failure • cytoskeleton


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
C. Etard, U. Roostalu, and U. Strahle
Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril
J. Cell Biol., March 24, 2008; 180(6): 1163 - 1175.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.