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Antiplatelet therapy in patients with claudication: lessons from large trials

J.A. Dormandy*

Vascular Division, St George's Hospital, London, U.K.

* Correspondence: John A. Dormandy, Clinical Research Centre - Vascular Division, Level 1, Ingleby House, St George's Hospital, Blackshaw Road, SW 17 OQT, London, U.K.

Abstract

There is now overwhelming evidence that the use of antiplatelet drugs in patients with intermittent claudication should be mandatory. The greater risk to patients with intermittent claudication is not progression of disease in the legs, but rather the increased risk for fatal and non-fatal cardiovascular events in other circulations. The incidence of such events can be reduced by the use of low-dose aspirin or clopidogrel. The effect of clopidogrel alone is greater than that of low-dose aspirin alone, but to obtain a significantly greater benefit from antiplatelet therapy the future probably lies in a combination of these two drugs, which affect platelet function through different pathways.

Key Words: Antiplatelet therapy • intermittent claudication • peripheral arterial disease • risk factors


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