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Strategy for ensuring a better future for the vessel wall

R. Corti, V. Fuster1 and J.J. Badimon

Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, New York, U.S.A.

1 Correspondence: Valentin Fuster, MD, PhD, Mount Sinai School of Medicine, Box 1030, New York, NY 10029, U.S.A.

Abstract

Prevention of cardiovascular events should involve an adequate control of the risk factors (diabetes, blood pressure, hyperlipidemia, etc). Once the thrombotic complications occur, the invasive approaches combined with potent antithrombotic agents appears to have some advantage over fibrinolytic therapy. A need for better and more efficacious antithrombotics is indicated by the high incidence of thrombotic complications. Among the new antothrombotic agents, the inhibition of the TF pathway (inhibitors of factors VIIa, Xa or oral thrombin inhibitors) seems to be more promising. Their efficacy should be demonstrated in large and controlled clinical trials.

Key Words: Cardiovascular diseases • atherosclerosis • lipids • thrombosis • thrombolysis


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