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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Perindopril/amlodipine combination: an optimal synergy for cardiovascular protection

Michel E. Bertrand*

Hôpital Cardiologique, Boulevard du Prof Leclercq 59037, Lille, France

* Corresponding author. Tel: +33 320 92 13 34, Fax: +33 320 00 65 09, E-mail address: mbcardio{at}club.fr

Within the last 20 years, several major therapeutic advances have markedly improved the prognosis of patients with coronary artery disease (CAD). Among these drugs, two of them [angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers] have demonstrated their beneficial effects in hypertensive patients. In addition, ACE inhibitors and particularly perindopril have shown a strong benefit in terms of secondary prevention in patients with stable CAD. Within the last 2 years, it has been shown that the simultaneous prescription of these drugs may reinforce their action and a synergistic effect might be observed. This paper reports a post hoc analysis of the EUROPA trial suggesting a clinical synergy of perindopril and calcium channel blockers in these particular patients. There was a significant relative risk reduction of the primary end point on combination perindopril/calcium channel blockers when compared with calcium channel blockers alone.

Key Words: ACE inhibitors • Calcium channel blockers • Perindopril • Amlodipine • Synergy


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