Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Lunde, K.
Right arrow Articles by Aakhus, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lunde, K.
Right arrow Articles by Aakhus, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Intracoronary injection of mononuclear bone marrow cells after acute myocardial infarction: lessons from the ASTAMI trial

Ketil Lunde* and Svend Aakhus

Department of Cardiology, Rikshospitalet University Hospital, Sognsvannsveien 20, 0027 Oslo, Norway

* Corresponding author. Tel: +47 23 07 41 46; fax: +47 23 24 18. E-mail address: ketil.lunde{at}rikshospitalet.no

We studied 100 patients with anterior wall acute myocardial infarction. Patients were randomized to intracoronary administration of autologous mononuclear bone marrow cells (n = 50) or a control group (n = 50). After 6 months follow-up, there was a similar improvement in global left ventricular ejection fraction in the groups. It has been suggested that suboptimal cell processing accounts for the negative results. However, cells processed according to the protocol used in the ASTAMI study are viable and proven to be efficacious for patients with haematological diseases. The ASTAMI study was powered to detect a 5% increase in LVEF, and our results do not exclude smaller effects of this treatment.

Key Words: Acute myocardial infarction • Bone marrow cells • Randomized clinical trial


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.